جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/1893/8854
Title: Drug exposure risk windows and unexposed comparator groups for cohort studies in pharmacoepidemiology
Authors: ASS Management and Support Team;Ninewells Hospital & Medical School;Ninewells Hospital & Medical School;Ninewells Hospital & Medical School
Keywords: Cohort study;Risk window;Unexposed group;Pharmacoepidemiology;MEMO
Publisher: John Wiley and Sons for the International Society for Pharmacoepidemiology
Description: Aim: To determine the appropriate size of risk windows in both exposed and unexposed sub-cohorts. Method: Data was taken from a previous study of upper gastrointestinal haemorrhage and perforation. The length of each prescription for NSAIDs was estimated. The risk was calculated for the duration of a prescription plus increments of -30, -25, ..., +115, +120 (i.e. 31 increments). Ten unexposed groups were re-sampled for each increment (stratified for age and sex), using the same lengths of risk window as the exposed group. Mean risks and rate-ratios were calculated (per thousand person-years). Results: The NSAID risk rose from 3·52 at -30 days to a peak of 5·82 at -15 days, and then decreased gradually to 2·83 at +120 days. Unexposed risk was variable for the negative increments, and decreased gradually from 2·16 at +0 days to 1·54 at +120 days. The rate-ratio rose from 1·55 at -30 days to a peak of 2·85 at -5 days, and then decreased to 1·85 at +120 days. Conclusion: Risk windows should be the same as (or slightly less than) the calculated length of a prescription. Lengthy windows should not be used for unexposed comparator groups (the exposed windows may be randomly allocated).
URI: http://dl.kums.ac.ir/handle/1893/8854
Standard no: http://hdl.handle.net/1893/8854
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1557(199807/08)7:4%3C275::AID-PDS363%3E3.0.CO;2-N/abstract
000075627500006
Appears in Collections:School of Health Sciences

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