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|Title:||Cyclin D1-positive diffuse large B-cell lymphoma with IGH-CCND1 translocation and BCL6 rearrangement: A report of two cases|
|Authors:||Al-Kawaaz, Mustafa;Mathew, Susan;Liu, Yifang;Gomez, Maria L.;Chaviano, Felicia;Knowles, Daniel M.;Orazi, Attilio;Tam, Wayne|
|Keywords:||BCL6 rearrangement;CCND1 rearrangement;Cyclin D1;Diffuse large B-cell lymphoma;Mantle cell lymphoma|
|Abstract:||Objectives: To demonstrate and confirm the existence of cyclin D1–positive diffuse large B-cell lymphoma (DLBCL) with IGH-CCND1 rearrangement and discuss the rationale of differentiating this entity from blastoid and pleomorphic variants of mantle cell lymphoma (MCL). Methods: Two cyclin D1–positive lymphomas with morphologic features of DLBCL and IGH-CCND1 translocations were characterized with respect to clinical features, as well as morphologic, immunophenotypic, cytogenetic, and molecular findings. Results: The large tumor cells were CD20+, CD5–, CD10–, BCL6+, MUM1+, and cyclin D1+ in both cases. SOX11 was negative. Epstein-Barr virus–encoded RNA in situ hybridization demonstrated diffuse positivity in case 1. BCL6 and IGH-CCND1 rearrangements were identified by fluorescence in situ hybridization in both cases. Specifically, the diagnosis of a relapsed DLBCL with acquisition of IGH-CCND1 was rendered for case 1, molecularly confirmed by the detection of identical monoclonal IGH rearrangements between the initial diagnostic DLBCL and relapse lymphoma. Conclusions: Our study demonstrates convincingly that IGH-CCND1 rearrangement leading to cyclin D1 overexpression can occur in DLBCL and pose a potential diagnostic pitfall, requiring thorough knowledge of the clinicopathologic findings to allow accurate discrimination from a blastoid or pleomorphic MCL. The coexistence of IGH-CCND1 and IGH-BCL6 rearrangements suggest that BCL6 and cyclin D1 may cooperate in the pathogenesis of DLBCL.|
|More Information:||Volume : 143Issue : 2Start page : 288|
END PAGES : 299
|Appears in Collections:||American Journal of Clinical Pathology|
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|2015 AJCP Volume 143 Issue 2 February (38).pdf||15.78 MB||Adobe PDF|
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