جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/122850
Title: Prognostic impact of fibrosarcomatous transformation in dermatofibrosarcoma protuberans: A cohort study
Authors: Hoesly, Paul M.;Lowe, Garrett C.;Lohse, Christine M.;Brewer, Jerry D.;Lehman, Julia S.
Keywords: cutaneous signs of disease;dermatofibrosarcoma protuberans;fibrosarcoma;oncogenesis;Pathology;Surgery
Issue Date: 2015
Publisher: Elsevier Inc
Abstract: Background Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade cutaneous malignancy that sometimes transforms into a high-grade fibrosarcomatous variant (DFSP-FS). Limited data compare clinical features and biological behavior of these 2 entities. Objective We sought to compare clinical features and biological behavior of DFSP and DFSP-FS. Methods This was a retrospective cohort study of ambulatory patients with DFSP or DFSP-FS treated between January 1955 and March 2012 in the dermatology department of a tertiary care academic medical center. Results Of 188 patients, 171 (91%) had DFSP and 17 (9%) had DFSP-FS. Recurrence-free survival differed significantly between the groups over time (P =.002). The 1-year and 5-year recurrence-free survival was 94% and 86%, respectively, for DFSP, vs 86% and 42%, respectively, for DFSP-FS. Metastatic disease occurred in no patients with DFSP and in 18% (3 of 17) with DFSP-FS (P <.001). There were no statistically significant differences in age at diagnosis, sex, race, symptomatology, maximum tumor size, muscle/bone invasion, or duration of tumor before diagnosis. Limitations The retrospective nature of study was a limitation. Conclusions DFSP-FS exhibits more aggressive behavior than DFSP, with lower recurrence-free survival and greater metastatic potential. Their similar clinical presentation mandates histopathological differentiation for prognosis.
URI: http://dx.doi.org/10.1016/j.jaad.2014.11.020
http://dl.kums.ac.ir/handle/Hannan/122850
ISSN: 0190-9622
volume: Volume 72
Issue: Issue 3
month: March
Format: Volume : 72Issue : 3Start page : 419
END PAGES : 425
Appears in Collections:Journal of The American Academy of Dermatology

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