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|Title:||Epidemiology of sinonasal squamous cell carcinoma: A comprehensive analysis of 4994 patients|
|Authors:||Sanghvi, Saurin;Khan, Mohemmed N.;Patel, Neal R.;Yeldandi, Swetha;Baredes, Soly;Eloy, Jean Anderson|
|Keywords:||Epidemiology;Squamous cell carcinoma;Surveillance;and End Result (SEER) database;Epidemiology;Incidence;long-term survival;malignancy;nasal cancer;paranasal sinus cancer;sinonasal cancer;Survival|
|Abstract:||OBJECTIVES/HYPOTHESIS: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database.\n\nSTUDY DESIGN: Retrospective cohort study using a national database.\n\nMETHODS: The SEER registry was utilized to calculate incidence and survival trends for patients with SNSCC between 1973 and 2009. Patient data were then analyzed according to age, sex, and race.\n\nRESULTS: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and "others" (P < .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. No significant differences (P > .05) were found when comparing survival between the last three decades. Differences in long-term survival were noted between whites, blacks, and "others," with whites displaying the highest 20-year survival. Males and females were found to have similar long-term survival curves, with 20-year survival of 30.68% and 26.35%, respectively.\n\nCONCLUSIONS: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.|
|ISSN:||1531-4995 (Electronic) 0023-852X (Linking)|
|More Information:||Volume : 124Issue : 1Start page : 76|
END PAGES : 83
|Appears in Collections:||Laryngoscope|
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