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|Title:||Defining the outcome of patients with delayed diagnosis of differentiated thyroid cancer.|
|Authors:||Amit, Moran;Rudnicki, Yaron;Binenbaum, Yoav;Trejo-Leider, Leonor;Cohen, Jacob T;Gil, Ziv|
|Keywords:||Adenocarcinoma;Adenocarcinoma: diagnosis;Adenocarcinoma: mortality;Adenocarcinoma: surgery;Biopsy, Fine-Needle;Delayed Diagnosis;Diagnosis, Differential;Disease-Free Survival;Female;Follow-Up Studies;Human;Israel;Israel: epidemiology;Male;Middle Aged;Neoplasm Staging;Neoplasm Staging: methods;Prognosis;Retrospective Studies;Survival Rate;Survival Rate: trends;Thyroid Neoplasms;Thyroid Neoplasms: diagnosis;Thyroid Neoplasms: mortality;Thyroid Neoplasms: surgery;Thyroidectomy;Time Factors|
|Abstract:||OBJECTIVES/HYPOTHESIS: In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC).\n\nSTUDY DESIGN: Retrospective medical record review and analysis of survival outcomes.\n\nMETHODS: The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome.\n\nRESULTS: Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n = 162) who underwent immediate surgery for similar disease.\n\nCONCLUSIONS: We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome.\n\nLEVEL OF EVIDENCE: 4.|
|More Information:||Volume : 124Issue : 12Start page : 2837|
END PAGES : 40
|Appears in Collections:||Laryngoscope|
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