جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/132520
Title: Nomogram for predicting symptom severity during radiation therapy for head and neck cancer
Authors: Sheu, T;Fuller, C D;Mendoza, T R;Garden, A S;Morrison, W H;Beadle, B M;Phan, J;Frank, S J;Hanna, E Y;Lu, C;Cleeland, C S;Rosenthal, D I;Gunn, G B
Keywords: MD Anderson Symptom Inventory Head and Neck Module;Adult;antineoplastic agent/dt [Drug Therapy];cancer localization;cancer patient;cancer radiotherapy;cancer surgery;carboplatin/dt [Drug Therapy];cetuximab/dt [Drug Therapy];chemoradiotherapy;cisplatin/dt [Drug Therapy];clinical assessment tool;clinical evaluation;controlled study;correlation analysis;disease severity;Female;head and neck cancer/dt [Drug Therapy];head and neck cancer/rt [Radiotherapy];head and neck cancer/su [Surgery];head and neck surgery;Human;hypopharynx cancer/dt [Drug Therapy];hypopharynx cancer/rt [Radiotherapy];hypopharynx cancer/su [Surgery];induction chemotherapy;intensity modulated radiation therapy;larynx cancer/dt [Drug Therapy];larynx cancer/rt [Radiotherapy];larynx cancer/su [Surgery];longitudinal study;major clinical study;Male;middle aged;mouth cancer/dt [Drug Therapy];mouth cancer/rt [Radiotherapy];mouth cancer/su [Surgery];multimodality cancer therapy;multivariate analysis;nasopharynx cancer/dt [Drug Therapy];nasopharynx cancer/rt [Radiotherapy];nasopharynx cancer/su [Surgery];nomogram;nose cancer/dt [Drug Therapy];nose cancer/rt [Radiotherapy];nose cancer/su [Surgery];oropharynx cancer/dt [Drug Therapy];oropharynx cancer/rt [Radiotherapy];outcome assessment;paranasal sinus cancer/dt [Drug Therapy];paranasal sinus cancer/rt [Radiotherapy];paranasal sinus cancer/su [Surgery];patient reported outcome;physician;platinum derivative/dt [Drug Therapy];predictor variable;primary tumor;prospective study;salivary gland cancer/dt [Drug Therapy];salivary gland cancer/rt [Radiotherapy];salivary gland cancer/su [Surgery];scoring system;symptom;taxane derivative/dt [Drug Therapy];tertiary health care;thyroid cancer/dt [Drug Therapy];thyroid cancer/rt [Radiotherapy];thyroid cancer/su [Surgery];trachea cancer/dt [Drug Therapy];trachea cancer/rt [Radiotherapy];trachea cancer/su [Surgery];treatment duration
Year: 2014
Abstract: Objectives. Radiation therapy (RT), with or without chemotherapy,can cause significant acute toxicity amongpatients treated for head and neck cancer (HNC), but predicting,before treatment, who will experience a particulartoxicity or symptom is difficult. We created and evaluated 2multivariate models and generated a nomogram to predictsymptom severity during RT based on a patient-reportedoutcome (PRO) instrument, the MD Anderson SymptomInventory-Head and Neck Module (MDASI-HN). Study Design. This was a prospective, longitudinal, questionnairebasedstudy. Setting. Tertiary cancer care center. Subjects and Methods. Subjects were 264 patients with HNC(mostly oropharyngeal) who had completed the MDASI-HNbefore and during therapy. Pretreatment variables were correlatedwith MDASI-HN symptom scores during therapywith multivariate modeling and then were correlated withthe composite MDASI-HN score during week 5 of therapy. Results. A multivariate model incorporating pretreatmentPROs better predicted MDASI-HN symptom scores duringtreatment than did a model based on clinical variables andphysician-rated patient performance status alone (Akaike informationcriterion = 1442.5 vs 1459.9). In the most parsimoniousmodel, pretreatment MDASI-HN symptom severity (P<.001), concurrent chemotherapy (P = .006), primary tumor site(P = .016), and receipt of definitive (rather than adjuvant) RT(P = .044) correlated with MDASI-HN symptom scores duringweek 5. That model was used to construct a nomogram. Conclusion. Our model demonstrates the value of incorporatingbaseline PROs, in addition to disease and treatmentcharacteristics, to predict patient symptom burden duringtherapy. Although additional investigation and validation arerequired, PRO-inclusive prediction tools can be useful forimproving symptom interventions and expectations forpatients being treated for HNC.
URI: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=2014895619\nhttp://sfx.ucl.ac.uk/sfx_local?sid=OVID:embase&id=pmid:&id=doi:10.1177%2F0194599814545746&issn=0194-5998&isbn=&volume=151&issue=4&spage=619&pages=619-626&date=2014&
http://dl.kums.ac.ir/handle/Hannan/132520
volume: Volume 151
Issue: Issue 4
month: October
More Information: Volume : 151Issue : 4Start page : 619
END PAGES : 626
Appears in Collections:Otolaryngology - Head and Neck Surgery

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