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|Title:||A subset of rosai-dorfman disease exhibits features of IgG4-related disease|
|Authors:||Zhang, Xuefeng;Hyjek, Elizabeth;Vardiman, James|
|Keywords:||IgG4;IgG4-related disease;Regulatory T cell;Rosai-Dorfman disease|
|Abstract:||In this study we investigated the distribution of IgG4+ plasma cells and regulatory T (T(REG)) cells, a major regulator of IgG4 production, in nodal and extranodal Rosai-Dorfman disease (RDD). Twenty-six specimens (15 nodal, 11 extranodal) were examined, with reactive lymph nodes and site-matched extranodal specimens as controls. Overall, 84.6% (22/26) of the specimens showed various degrees of sclerosis (7 mild, 8 moderate, and 7 severe). Nineteen cases (73.1%) exhibited more than 10 IgG4+ cells/0.060 mm(2) (photographed area at ×40), and 8 cases (30.8%) showed more than 40% of IgG+ cells being IgG4+. Only 1 control case exhibited more than 10 IgG4+ cells/0.060 mm(2) (P < .05). The number of T(REG) cells was comparable between nodal RDD and controls, whereas extranodal RDD exhibited significantly higher numbers of T(REG) cells than controls. These findings demonstrate that a subset of RDD shows features of IgG4-related disease and indicate an overlap between certain aspects of the 2 diseases.|
|More Information:||VOLUME : 139ISSUE : 5START PAGE : 622|
END PAGES : 632
|Appears in Collections:||American Journal of Clinical Pathology|
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