جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/22268
Title: HIV infection is associated with decreased thrombin generation
Authors: Hsue, P Y;Scherzer, R;Grunfeld, C;Nordstrom, S M;Schnell, a;Kohl, L P;Nitta, E;Martin, J N;Deeks, S G;Weiss, E J
Keywords: Adult;Anti-HIV Agents;Antithrombins;Blood Coagulation Disorders;Disease;HIV Infections;Hiv;Human;Male;Middle Aged;Morbidity;Plasma;Prothrombin;Risk;Thrombin;analysis;Complications;drug therapy;Epidemiology;Methods;Mortality;physiopathology;therapeutic us
Issue Date: 2012
Abstract: BACKGROUND: Excess risk of cardiovascular disease occurs in effectively treated individuals with human immunodeficiency virus (HIV) infection. Although elevated plasma D-dimer levels are associated with increased morbidity and mortality, the impact of HIV infection on coagulation in vivo has not been well studied. METHODS: We measured D-dimers, antithrombin, endogenous thrombin potential (ETP; a functional measure of thrombin generation in vitro), thrombin/antithrombin complexes (TAT; a measure of thrombin generation in vivo), tissue factor, prothrombin fragment 1 + 2 (F1+2), and normalized APC sensitivity ratio (nAPCsr) in 199 HIV-positive men who were receiving antiretroviral therapy and had an undetectable HIV RNA level, in 79 HIV-positive untreated men, and in 39 uninfected controls. RESULTS: Median antithrombin levels were higher while the ETP was lower among HIV-infected adults (treated and untreated), compared with controls. There were few differences between coagulation markers in the 2 HIV groups. Compared with controls, the nAPCsr was lower in treated men and the TAT level was lower in untreated individuals. We observed little difference among measured levels of D-dimer, tissue factor, or F1+2 between HIV-infected individuals and controls. Antiretroviral therapy exposure was associated with a lower antithrombin level, a lower nAPCsr, and a lower ETP, while history of opportunistic infection was associated with a higher nAPCsr. CONCLUSIONS: HIV infection is associated with decreased thrombin generation, as measured by the ETP, and an increased antithrombin level. These data suggest that HIV infection may not be associated with increased propensity toward clotting, as has been suggested on the basis of isolated measures of D-dimer levels
URI: http://dl.kums.ac.ir/handle/Hannan/22268
Format: VOLUME : 54ISSUE : 1537-6591 (Electronic)START PAGE : 1196
END PAGES : 1203
Appears in Collections:Clinical Infectious Diseases

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