صفحه اصلی مجموعه  Journal of Medicinal Chemistry

RSS Feed


PreviewIssue DateTitleContributor(s)
130.pdf.jpg24-Jun-2014The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones as Orally Bioavailable Antitumor AgentsSampson, Peter B; Liu, Yong; Patel, Narendra Kumar; Feher, Miklos; Forrest, Bryan; Li, Sze-Wan; Edwards, Louise; Laufer, Radoslaw; Lang, Yunhui; Ban, Fuqiang; Awrey, Donald E; Mao, Guodong; Plotnikova, Olga; Leung, Genie; Hodgson, Richard; Mason, Jacqueline; Wei, Xin; Kiarash, Reza; Green, Erin; Qiu, Wei; Chirgadze, Nickolay Y; Mak, Tak W; Pan, Guohua; Pauls, Henry W
2016 JMC Volume 59 Issue 3 February (25).pdf.jpg2016Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric DiseasesLi, Peng; Zheng, Hailin; Zhao, Jun; Zhang, Lei; Yao, Wei; Zhu, Hongwen; Beard, J David; Ida, Koh; Lane, Weston; Snell, Gyorgy; Sogabe, Satoshi; Heyser, Charles J; Snyder, Gretchen L; Hendrick, Joseph P; Vanover, Kimberly E; Davis, Robert E; Wennogle, Lawrence P
2016 JMC Volume 59 Issue 3 February (20).pdf.jpg2016Discovery of Potent, Selective, and Orally Bioavailable Small- Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19Schiemann, Kai; Rink, Christian; Stieber, Frank; Calderini, Michel; Crumpler, Simon; Stubbs, Mark; Adeniji-popoola, Olajumoke; Poeschke, Oliver; Busch, Michael; Czodrowski, Paul; Musil, Djordje; Schwarz, Daniel; Schneider, Richard; Thai, Ching; Valenti, Melanie; Brandon
2016 JMC Volume 59 Issue 3 February (26).pdf.jpg2016Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) FamilyHuard, Kim; Gosset, James R; Montgomery, Justin I; Gilbert, Adam; Hayward, Matthew M; Magee, Thomas V; Cabral, Shawn; Uccello, Daniel P; Bahnck, Kevin; Brown, Janice; Purkal, Julie; Gorgoglione, Matthew; Lanba, Adhiraj; Futatsugi, Kentaro; Herr, Michael; Genung, Nathan
2016 JMC Volume 59 Issue 3 February (24).pdf.jpg2016Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1Llona-minguez, Sabin; Ho, Andreas; Jacques, Sylvain A; Johansson, Lars; Manuel, Jose; Claesson, Magnus; Loseva, Olga; Valerie, Nicholas C K; Piedra, Javier; Maga, Giovanni; Crespan, Emmanuele; Meijer, Laurent; Jensen, Annika Jenmalm; Artursson, Per; Jemth, Ann-so; Stenm
2016 JMC Volume 59 Issue 3 February (27).pdf.jpg2016Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment InhibitorFreitas, Renato Ferreira De; Eram, Mohammad S; Szewczyk, Magdalena M; Steuber, Holger; Smil, David; Wu, Hong; Li, Fengling; Senisterra, Guillermo; Dong, Aiping; Brown, Peter J; Hitchcock, Marion; Moosmayer, Dieter; Stegmann, Christian M; Egner, Ursula; Arrowsmith, Cher
2016 JMC Volume 59 Issue 3 February (19).pdf.jpg2016Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin BGallardo-godoy, Alejandra; Muldoon, Craig; Becker, Bernd; Elliott, Alysha G; Lash, Lawrence H; Huang, Johnny X; Butler, Mark S; Pelingon, Ruby; Kavanagh, Angela M; Ramu, Soumya; Phetsang, Wanida; Blaskovich, Mark A T; Cooper, Matthew A
2016 JMC Volume 59 Issue 3 February (2).pdf.jpg2016Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus InfectionHe, Shanshan; Xiao, Jingbo; Dulcey, E; Lin, Billy; Rolt, Adam; Hu, Zongyi; Hu, Xin; Wang, Amy Q; Xu, Xin; Southall, Noel; Ferrer, Marc; Zheng, Wei; Liang, T Jake; Marugan, Juan J
2016 JMC Volume 59 Issue 3 February (21).pdf.jpg2016The E ff ect of Small Molecules on Sterol Homeostasis: Measuring 7 ‑ Dehydrocholesterol in Dhcr7-De fi cient Neuro2a Cells and Human FibroblastsKorade, Zeljka; Kim, Hye-young H; Tallman, Keri A; Liu, Wei; Koczok, Katalin; Balogh, Istvan; Xu, Libin; Mirnics, Karoly; Porter, Ned A
2016 JMC Volume 59 Issue 3 February (22).pdf.jpg2016Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor − Nuclear Receptor Related 1 Protein Dimer ActivationBurstein, Ethan S; Ottmann, Christian; Brunsveld, Luc; Olsson, Roger
2016 JMC Volume 59 Issue 6 March (18).pdf.jpg2016Amgen Incorporated, 360 Binney Street, Cambridge, Massachusetts 02142, United States Amgen Incorporated, One Amgen Center Drive, Thousand Oaks, California 91320, United StatesBoezio, Alessandro A; Copeland, Katrina W; Rex, Karen; Albrecht, Brian K; Bauer, David; Bellon, Steven F; Boezio, Christiane; Broome, Martin A; Choquette, Deborah; Coxon, Angela; Dussault, Isabelle; Hirai, Satoko; Lewis, Richard; Lin, Min-hwa Jasmine; Lohman, Julia; Liu
2016 JMC Volume 59 Issue 6 March (16).pdf.jpg2016Andrew M. Thompson, * , † Patrick D. O ’ Connor, † Adrian Blaser, † Vanessa Yardley, ‡ Louis Maes, § Suman Gupta, ∥ Delphine Launay, ⊥ Denis Martin, ⊥ Scott G. Franzblau, # Baojie Wan, # Yuehong Wang, # Zhenkun Ma, ¶ and William A. Denny † †Thompson, Andrew M; Connor, Patrick D O; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A
2016 JMC Volume 59 Issue 6 March (19).pdf.jpg2016Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell SurvivalKettle, Jason G; Alwan, Husam; Bista, Michal; Breed, Jason; Davies, Nichola L; Eckersley, Kay; Fillery, Shaun; Foote, Kevin M; Goodwin, Louise; Jones, David R; Ka, Helena; Lau, Alan; Nissink, J Willem M; Read, Jon; Scott, James S; Taylor, Ben; Walker, Graeme; Wissler, Lis
2016 JMC Volume 59 Issue 6 March (14).pdf.jpg2016Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3 ‑ Kinase (PI3K)Protein, Allosteric Mitogen-activated; Mek, Kinase; Pik, Phosphatidylinositol Kinase; Dort, Marcian E Van; Hong, Hao; Wang, Hanxiao; Nino, Charles A; Lombardi, Rachel L; Blanks, Avery E; Galba, Stefanie; Ross, Brian D
2016 JMC Volume 59 Issue 6 March (20).pdf.jpg2016Rational Design, Synthesis, and Preliminary Structure − Activity Relationships of α ‑ Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O ‑ Acetylserine SulfhydrylasePieroni, Marco; Annunziato, Giannamaria; Beato, Claudia; Wouters, Randy; Benoni, Roberto; Campanini, Barbara; Pertinhez, Thelma A; Bettati, Stefano; Mozzarelli, Andrea; Costantino, Gabriele
2016 JMC Volume 59 Issue 6 March (21).pdf.jpg2016Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid HydroxylaseDiaz, Philippe; Huang, Weize; Keyari, Charles M; Buttrick, Brian; Price, Lauren; Guilloteau, Nicolas; Tripathy, Sasmita; Sperandio, Vanessa G; Fronczek, Frank R; Astruc-diaz, Fanny; Isoherranen, Nina
2016 JMC Volume 59 Issue 6 March (17).pdf.jpg2016Design and Synthesis of Benzimidazoles As Novel Corticotropin- Releasing Factor 1 Receptor AntagonistsMochizuki, Michiyo; Kori, Masakuni; Kobayashi, Katsumi; Yano, Takahiko; Sako, Yuu; Tanaka, Maiko; Kanzaki, Naoyuki; Gyorkos, Albert C; Corrette, Christopher P; Cho, Suk Young; Pratt, Scott A; Aso, Kazuyoshi
2016 JMC Volume 59 Issue 6 March (15).pdf.jpg2016Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine DevelopmentJacob, Nicholas T; Lockner, Jonathan W; Schlosburg, Joel E; Ellis, Beverly A; Eubanks, Lisa M; Janda, Kim D
2016 JMC Volume 59 Issue 6 March (2).pdf.jpg2016Rho Kinase ( ROCK ) Inhibitors and Their Therapeutic PotentialFeng, Yangbo; Lograsso, Philip V; Defert, Olivier; Li, Rongshi
2016 JMC Volume 59 Issue 1 January (29).pdf.jpg2016Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K δ InhibitorsShin, Youngsook; Suchomel, Julia; Cardozo, Mario; Duquette, Jason; He, Xiao; Henne, Kirk; Hu, Yi-ling; Kelly, Ron C; Mccarter, John; Mcgee, Lawrence R; Medina, Julio C; Metz, Daniela; Miguel, Tisha San; Mohn, Deanna; Tran, Thuy; Vissinga, Christine; Wong, Simon; Wannberg,