جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/270101
Title: Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma
Authors: Zhao, Jingzhu;Chi, Jiadong;Gao, Ming;Zhi, Jingtai;Li, Yigong;Zheng, Xiangqian
Keywords: Medical Science
Issue Date: 2017
Publisher: American Association of Oral and Maxillofacial Surgeons
Abstract: Purpose The aim of this study was to detect the relationship between phosphatase and tensin homolog deletion on chromosome 10 (PTEN) and microRNA 24 (miR-24) and correlate PTEN expression with important clinical parameters of patients with tongue squamous cell carcinoma (TSCC). Materials and Methods In this retrospective case series, all TSCC patients treated at Tianjin Medical University Cancer Institute and Hospital between March 2005 and October 2011 were retrospectively reviewed. Demographic information and clinical data (histologic type, clinical stage, tumor differentiation, and so on) were collected. The miR-24 level was detected by quantitative reverse transcription–polymerase chain reaction. The PTEN level was analyzed by immunohistochemistry and quantitative reverse transcription–polymerase chain reaction. Data analyses were performed by Spearman correlation analysis, Pearson χ2test, and paired t test. Kaplan-Meier curves, log-rank analyses, and a Cox proportional hazards model were used to evaluate the prognostic value of PTEN. Results A total of 90 patients (aged 59.4 ± 9.5 years, 53 men and 37 women) were identified. Loss of PTEN expression was detected in 28 of 90 tumors (31.1%). The PTEN messenger RNA level was negatively correlated with the miR-24 level (r = −0.569, P <.01). PTEN expression also was negatively correlated with the miR-24 level (r = −0.621, P <.01). Furthermore, PTEN expression was significantly lower in cancer tissues than in adjacent normal tissues, and its expression was negatively correlated with clinical stage (P <.01) and positively correlated with differentiation (P <.05) in TSCC patients. In addition, the Kaplan-Meier curve indicated that loss of PTEN expression resulted in poor survival of TSCC patients (P <.01). Multivariate analysis indicated that PTEN expression level and clinical stage may be independent prognostic factors for TSCC patients. Conclusions This study suggested that PTEN expression was negatively correlated with the miR-24 level in TSCC. The loss of PTEN expression may serve as a predictor of unfavorable prognosis for TSCC patients.
URI: http://dx.doi.org/10.1016/j.joms.2017.03.025
http://dl.kums.ac.ir/handle/Hannan/270101
ISSN: 
volume: Volume 75
Issue: Issue 7
month: July
Format: VOLUME:75
ISSUE:7
STARTPAGE:1449.e1
ENDPAGES:1449.e8
Appears in Collections:Journal of Oral and Maxillofacial Surgery ( JOMS)

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