جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/30808
Title: G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonists reduce the production of proinflammatory cytokines and stabilize the alternative macrophage phenotype
Authors: K., Hogenauer;L., Arista;N., Schmiedeberg;G., Werner;H., Jaksche;R., Bouhelal;D.G., Nguyen;B.G., Bhat;L., Raad;C., Rauld;J.M., Carballido
Keywords: 3 methyl n phenethyl n phenylisonicotinamide;4 fluoro 2 methyl n ((2 methyl 1h indol 4 yl)methy;EC50;G protein coupled receptor;Th1 cell;Th17 cell;animal cell;animal experiment;animal model;antiinflammatory activity;area under the curve;cell differentiation;controlled study;cytokine;cytokine production;cytokine release;dexamethasone;drug absorption;drug bioavailability;drug clearance;drug development;drug half life;drug identification;drug potency;drug structure;drug synthesis;g protein coupled bile acid receptor 1;gamma interferon;high throughput screening;Human;human cell;immunomodulation;in vitro study;in vivo study;Inflammation;interleukin 10;interleukin 12;interleukin 1beta;isonicotinamide;knockout mouse;lipophilicity;lipopolysaccharide;lithium 3 methylpyridazine 4 carboxylate;liver microsome;macrophage;Male;maximum plasma concentration;monocyte;mouse;n (2 methoxybenzyl) 2 (trifluoromethoxy)aniline;n (2 methoxybenzyl) 3 methyl n (2 (trifluoromethox;n (2 methoxybenzyl) 3 methyl n phenylisonicotinami;n (3,5 dichlorophenyl) n (2 methoxybenzyl) 3 methy;n (4 fluoro 2 methylphenyl) 3 methyl n ((2 methyl;n benzyl 1,4 dimethyl n phenyl 1h imidazole 5 carb;n benzyl 2 methyl n phenylisonicotinamide;n benzyl 3 methyl n phenylisonicotinamide;n benzyl 3 methyl n phenylpyridazine 4 carboxamide;n benzyl 3,5 dimethyl n phenylisoxazole 4 carboxam;n benzyl 4 methyl n phenylnicotinamide;n benzyl n phenylisonicotinamide;n isobutyl 3 methyl n phenylisonicotinamide;n,n dibenzyl 3 methylisonicotinamide;nonhuman;nonsteroid antiinflammatory agent;phenotype;protein expression;structure activity relation;time to maximum plasma concentration;treatment response;tumor necrosis factor alpha;unclassified drug
Year: 2014
Abstract: GPBAR1 (also known as TGR5) is a G-protein-coupled receptor (GPCR) that triggers intracellular signals upon ligation by various bile acids. The receptor has been studied mainly for its function in energy expenditure and glucose homeostasis, and there is l
URI: http://dl.kums.ac.ir/handle/Hannan/30808
More Information: VOLUME : 57ISSUE : 24START PAGE : 10343
END PAGES : 10354
Appears in Collections:Journal of Medicinal Chemistry

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