جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/30844
Title: In vivo phenotypic screening for treating chronic neuropathic pain: Modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists
Authors: Tosh, D K;Finley, a;Paoletta, S;Moss, S M;Gao, Z.-G.;Gizewski, E T;Auchampach, J a;Salvemini, D;Jacobson, K a
Keywords: (1,2,3,4,5) 2,3 dihydroxy 4 [2 [(2 methoxyphenyl)e;(1,2,3,4,5) 2,3 dihydroxy 4 [2 [(3 methoxyphenyl)e;(1,2,3,4,5) 2,3 dihydroxy 4 [2 [(4 hydroxymethyl)p;(1,2,3,4,5) 2,3 dihydroxy 4 [2 [(4 methoxyphenyl)e;(1,2,3,4,5) 2,3 dihydroxy n methyl 4 [2 [(1 methyl;(1,2,3,4,5) 2,3 dihydroxy n methyl 4 [6 (methylami;(1,2,3,4,5) 4 [2 (benzofuran 2 ylethynyl) 6 (methy;(1,2,3,4,5) 4 [2 (furan 2 ylethynyl) 6 (methylamin;(1,2,3,4,5) 4 [2 [(1h pyrazol 3 yl)ethynyl] 6 (met;(1,2,3,4,5) 4 [2 [(4,5 dimethylfuran 2 yl)ethynyl];(1,2,3,4,5) 4 [2 [(5 bromothiophen 2 yl)ethynyl] 6;(1,2,3,4,5) 4 [2 [(5 chlorothiophen 2 yl)ethynyl];(1,2,3,4,5) 4 [2 [(5 ethylfuran 2 yl)ethynyl] 6 (m;(1,2,3,4,5) 4 [2 [(ferrocen yl)ethynyl] 6 (methyla;A3 adenosine receptor agonist;adenosine receptor stimulating agent;amide;animal experiment;animal model;binding affinity;biogenic amine;chronic constriction injury;chronic neuropathic pain;chronic pain;ferrocene derivative;Human;in vivo study;methyl group;mouse;mrs 5698;neuropathic pain;nonhuman;physical chemistry;receptor;unclassified drug
Year: 2014
Abstract: (N)-Methanocarba adenosine 5′-methyluronamides containing 2-arylethynyl groups were synthesized as A3 adenosine receptor (AR) agonists and screened in vivo (po) for reduction of neuropathic pain. A small N6-methyl group maintained binding affinity, with h
URI: http://dl.kums.ac.ir/handle/Hannan/30844
More Information: VOLUME : 57ISSUE : 23START PAGE : 9901
END PAGES : 9914
Appears in Collections:Journal of Medicinal Chemistry

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