جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.kums.ac.ir/handle/Hannan/54709
Title: Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgery.
Authors: Caputo, Massimo;Mokhtari, Amir;Miceli, Antonio;Ghorbel, Mohamed T;Angelini, Gianni D;Parry, Andrew J;Suleiman, Saadeh M
Keywords: Age Factors;Biological Markers;Biological Markers: blood;Cardiac Surgical Procedures;Cardiac Surgical Procedures: adverse effects;Cardiopulmonary Bypass;Cardiopulmonary Bypass: adverse effects;Child;Child, Preschool;Dinoprost;Dinoprost: analogs & derivati
Year: 2014
Publisher: Elsevier Inc.
Abstract: OBJECTIVE: Single-ventricle patients undergoing pediatric heart surgery are a high-risk group owing to reoxygenation injury during cardiopulmonary bypass (CPB). The present study investigated the effects of controlled reoxygenation CPB on biomarkers of organ damage, inflammation, stress, and long-term functional outcomes in cyanotic patients with either a single or double ventricle during open heart surgery.\n\nMETHODS: Cyanotic patients with either a single (n = 32) or double (n = 47) ventricle undergoing surgical correction were randomized to receive CPB using either standard oxygen levels or controlled reoxygenation. The markers of cardiac injury, inflammation, stress, and cerebral and hepatic injury were measured preoperatively, at 10 and 30 minutes after starting CPB, and at 10 minutes and 4 and 24 hours after CPB. The data were analyzed using a mixed regression model.\n\nRESULTS: No difference was found in the pre- or intraoperative characteristics between the standard and controlled reoxygenation CPB groups for single- or double-ventricle patients. In the single-ventricle patients, controlled reoxygenation CPB significantly (P < .05) decreased the markers of organ damage, inflammation, stress, and oxidative stress. In contrast, the markers of inflammation and cardiac injury were not altered by controlled reoxygenation CPB in the double-ventricle patients.\n\nCONCLUSIONS: Controlled reoxygenation CPB decreased the markers of organ damage, stress, inflammation, and oxidative stress in single-ventricle patients undergoing cardiac surgery.
URI: http://dl.kums.ac.ir/handle/Hannan/54709
ISSN: 1097-685X (Electronic)\r0022-5223 (Linking)
More Information: VOLUME : 148ISSUE : 3START PAGE : 792
END PAGES : 801.e8; discussion 800-1
Appears in Collections:Journal of the thoracis and cardiovascular surgery

Files in This Item:
File Description SizeFormat 
2014medicine article m (216).pdf1.69 MBAdobe PDFThumbnail
Download    Request a copy


تمامی کاربرگه ها در کتابخانه ی دیجیتال حنان به صورت کامل محافظت می شوند.